منابع مشابه
Composition of the synaptic PSD-95 complex.
Postsynaptic density protein 95 (PSD-95), a specialized scaffold protein with multiple protein interaction domains, forms the backbone of an extensive postsynaptic protein complex that organizes receptors and signal transduction molecules at the synaptic contact zone. Large, detergent-insoluble PSD-95-based postsynaptic complexes can be affinity-purified from conventional PSD fractions using ma...
متن کاملComposition of the Synaptic PSD-95 Complex*□S
Postsynaptic density protein 95 (PSD-95), a specialized scaffold protein with multiple protein interaction domains, forms the backbone of an extensive postsynaptic protein complex that organizes receptors and signal transduction molecules at the synaptic contact zone. Large, detergentinsoluble PSD-95-based postsynaptic complexes can be affinity-purified from conventional PSD fractions using mag...
متن کاملSynaptic Accumulation of PSD-95 and Synaptic Function Regulated by Phosphorylation of Serine-295 of PSD-95
The scaffold protein PSD-95 promotes the maturation and strengthening of excitatory synapses, functions that require proper localization of PSD-95 in the postsynaptic density (PSD). Here we report that phosphorylation of ser-295 enhances the synaptic accumulation of PSD-95 and the ability of PSD-95 to recruit surface AMPA receptors and potentiate excitatory postsynaptic currents. We present evi...
متن کاملCellular/Molecular PSD-95 Uncouples Dopamine–Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex
Jingping Zhang,1 Tai-Xiang Xu,1 Penelope J. Hallett,2 Masahiko Watanabe,3 Seth G. N. Grant,4 Ole Isacson,2 and Wei-Dong Yao1 1New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, 2McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, 3Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan, and 4Wellcome ...
متن کاملPSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex.
Classical dopaminergic signaling paradigms and emerging studies on direct physical interactions between the D(1) dopamine (DA) receptor and the NMDA glutamate receptor predict a reciprocally facilitating, positive feedback loop. This loop, if not controlled, may cause concomitant overactivation of both D(1) and NMDA receptors, triggering neurotoxicity. Endogenous protective mechanisms must exis...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2007
ISSN: 1535-9476
DOI: 10.1074/mcp.m700040-mcp200